Proteolysis in the Escherichia coli heat shock response: a player at many levels
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Baker_Proteolysis in.pdf
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Author(s)
Meyer, Anne S.
Baker, Tania
Date Issued
February 2011
Journal
Current Opinion in Microbiology
Publisher
Elsevier
Citation
Meyer, Anne S, and Tania A Baker. “Proteolysis in the Escherichia Coli Heat Shock Response: a Player at Many Levels.” Current Opinion in Microbiology 14, no. 2 (April 2011): 194–199.
Version
Author's final manuscript
Abstract
Proteolysis is a fundamental process used by all forms of life to maintain homeostasis, as well as to remodel the proteome following environmental changes. Here, we explore recent advances in understanding the role of proteolysis during the heat shock response of Escherichia coli. Proteolysis both regulates and contributes directly to and the heat shock response at multiple different levels, from adjusting the levels of the master heat shock response regulator (σ[superscript 32]), to eliminating damaged cellular proteins, to altering the activity of chaperones that refold heat-denatured proteins. Recent results illustrate the complexity of the heat shock response and the pervasive role that proteolysis plays in both the cellular response to heat shock and the subsequent limiting of the response, as cells return to a more ‘normal’ physiological state.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.mib.2011.02.001
