NIR-Sensitive Au-Au₂S Nanoparticles for Drug Delivery
Name
MEBCS021.pdf
Size
99.26 KB
Format
Adobe PDF
Checksum (MD5)
104128e9b501fc8d83083cfd4d301b42
Author(s)
Ren, L.
Chow, Gan-Moog
Date Issued
January 2003
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Near IR (NIR) sensitive Au-Au₂S nanoparticles were prepared by mixing HAuCl₄ and Na₂S in aqueous solutions. An anti-tumor drug, cis-platin, was adsorbed onto Au-Au₂S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au₂S nanoparticles was controlled by the pH value of solution, and the drug release was sensitive to NIR irradiation. The cis-platin loaded Au-Au₂S nanoparticles can be potentially applied as NIR activated drug delivery carrier.
Subjects
drug delivery
near-infrared
Au-Au2
nanoparticles
cis-Platin
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