Can We Build Artificial Stem Cell Compartments?
Name
2738.2003.313828.pdf
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536.72 KB
Format
Adobe PDF
Checksum (MD5)
78863ba2aed4b824bc561db4101e75cf
Author(s)
Semino, Carlos E.
Date Issued
2003
Journal
Journal of Biomedicine and Biotechnology
Publisher
Hindawi Publishing Corporation
Citation
Semino, Carlos E. “Can We Build Artificial Stem Cell Compartments?” Journal of Biomedicine and Biotechnology 2003, no. 3 (2003): 164–169. © 2003 Hindawi Publishing Corporation
Version
Final published version
Abstract
Animals carry stem cells throughout their entire life, from embryogenesis to senescence. Their function during development and adulthood consists basically of forming and sustaining functional tissues while maintaining a small self-renewing population. They reside in a complex three-dimensional environment consisting of other nearby cells extracellular matrix components, endogenous or exogenous soluble factors, and physical, structural, or mechanical properties of the tissues they inhabit. Can we artificially recreate tissue development such that stem cells can both self-renew and be instructed to mature properly? The main factors required to regulate the maintenance and differentiation of some types of stem cells are known. In addition, new bioengineered synthetic materials that mimic extracellular matrix components can be used as initial scaffolding for building stem cell microenvironments.
MIT Department
Massachusetts Institute of Technology. Biotechnology Process Engineering Center
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1155/S1110724303208019
