Emerging immunomodulatory strategies for cell therapeutics
Name
1-s2.0-S0167779922003055-main.pdf
Description
Published version
Size
2.42 MB
Format
Adobe PDF
Checksum (MD5)
e91c34b063d46e8f2aa64d17e20f12e0
Author(s)
Chua, Corrine Ying Xuan
Jiang, Allen Yujie
Eufrásio-da-Silva, Tatiane
Dolatshahi-Pirouz, Alireza
Langer, Robert
Orive, Gorka
Grattoni, Alessandro
Date Issued
March 2023
Journal
Trends in Biotechnology
Publisher
Elsevier BV
Citation
Chua, Corrine Ying Xuan, Jiang, Allen Yujie, Eufrásio-da-Silva, Tatiane, Dolatshahi-Pirouz, Alireza, Langer, Robert et al. 2023. "Emerging immunomodulatory strategies for cell therapeutics." Trends in Biotechnology, 41 (3).
Version
Final published version
Abstract
Cellular therapies are poised to transform the field of medicine by restoring dysfunctional tissues and treating various diseases in a dynamic manner not achievable by conventional pharmaceutics. Spanning various therapeutic areas inclusive of cancer, regenerative medicine, and immune disorders, cellular therapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune response presents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immune tolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.tibtech.2022.11.008
