Engineering Stem Cell Organoids
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Langer_Stem cell.pdf
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1.51 MB
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Author(s)
Safaee, Helia
Levy, Oren
Yin, Xiaolei
Mead, Benjamin Elliott
Langer, Robert S
Karp, Jeffrey Michael
Alternative Title
Engineering Stem Cell Organoids
Date Issued
January 2016
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Yin, Xiaolei; Mead, Benjamin E.; Safaee, Helia; Langer, Robert; Karp, Jeffrey M. and Levy, Oren. “Engineering Stem Cell Organoids.” Cell Stem Cell 18, no. 1 (January 2016): 25–38 © 2016 Elsevier Inc
Version
Author's final manuscript
Abstract
Organoid systems leverage the self-organizing properties of stem cells to create diverse multi-cellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell-cell/cell-matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell-based organoids, their advantages and limitations, and how bioengineering strategies can be used to steer the cell composition and their 3D organization within organoids to further enhance their utility in research and therapies.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.stem.2015.12.005
