Solvent-Free Dynamic Nuclear Polarization of Amorphous and Crystalline ortho-Terphenyl
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Author(s)
Ong, Ta-Chung
Mak-Jurkauskas, Melody L.
Michaelis, Vladimir K.
Smith, Albert A.
Clausen, Andrew M.
Cheetham, Janet C.
Walish, Joseph John
Corzilius, Bjorn
Griffin, Robert Guy
Swager, Timothy M
Date Issued
February 2013
Journal
Journal of Physical Chemistry B
Publisher
American Chemical Society (ACS)
Citation
Ong, Ta-Chung, Melody L. Mak-Jurkauskas, Joseph J. Walish, Vladimir K. Michaelis, Björn Corzilius, Albert A. Smith, Andrew M. Clausen, Janet C. Cheetham, Timothy M. Swager, and Robert G. Griffin. “Solvent-Free Dynamic Nuclear Polarization of Amorphous and Crystalline Ortho-Terphenyl .” The Journal of Physical Chemistry B 117, no. 10 (March 14, 2013): 3040–3046.
Version
Author's final manuscript
Abstract
Dynamic nuclear polarization (DNP) of amorphous and crystalline ortho-terphenyl (OTP) in the absence of glass forming agents is presented in order to gauge the feasibility of applying DNP to pharmaceutical solid-state nuclear magnetic resonance experiments and to study the effect of intermolecular structure, or lack thereof, on the DNP enhancement. By way of [superscript 1]H–[superscript 13]C cross-polarization, we obtained a DNP enhancement (ε) of 58 for 95% deuterated OTP in the amorphous state using the biradical bis-TEMPO terephthalate (bTtereph) and ε of 36 in the crystalline state. Measurements of the [superscript 1]H T[subscript 1] and electron paramagnetic resonance experiments showed the crystallization process led to phase separation of the polarization agent, creating an inhomogeneous distribution of radicals within the sample. Consequently, the effective radical concentration was decreased in the bulk OTP phase, and long-range [superscript 1]H–[superscript 1]H spin diffusion was the main polarization propagation mechanism. Preliminary DNP experiments with the glass-forming anti-inflammation drug, indomethacin, showed promising results, and further studies are underway to prepare DNP samples using pharmaceutical techniques.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology)
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DOI of Published Version
https://doi.org/10.1021/jp311237d
