Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs
Name
Adv Healthcare Materials - 2021 - Bora - Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule.pdf
Description
Published version
Size
1.81 MB
Format
Adobe PDF
Checksum (MD5)
17f2342702c306fbf59df2b10ee1babd
Author(s)
Bora, Meghali
Hsu, Myat Noe
Khan, Saif A
Doyle, Patrick S
Date Issued
April 2022
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Bora, Meghali, Hsu, Myat Noe, Khan, Saif A and Doyle, Patrick S. 2022. "Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs." Advanced Healthcare Materials, 11 (8).
Version
Final published version
Abstract
Conventional formulation strategies for hydrophobic small‐molecule drug products frequently include mechanical milling to decrease active pharmaceutical ingredient (API) crystal size and subsequent granulation processes to produce an easily handled powder. A hydrogel‐templated anti‐solvent crystallization method is presented for the facile fabrication of microparticles containing dispersed nanocrystals of poorly soluble API. Direct crystallization within a porous hydrogel particle template yields core–shell structures in which the hydrogel core containing API nanocrystals is encased by a crystalline API shell. The process of controllable loading (up to 64% w/w) is demonstrated, and tailored dissolution profiles are achieved by simply altering the template particle size. API release is well described by a shrinking core model. Overall, the approach is a simple, scalable and potentially generalizable method that enables novel means of independently controlling both API crystallization and excipient characteristics, offering a “designer” drug particle system.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adhm.202102252
