Impulse Control: Temporal Dynamics in Gene Transcription
Name
Yosef-2011-Impulse Control_ Tem.pdf
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882.35 KB
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Author(s)
Yosef, Nir
Regev, Aviv
Date Issued
March 2011
Journal
Cell
Publisher
Elsevier B.V.
Citation
Yosef, Nir, and Aviv Regev. “Impulse Control: Temporal Dynamics in Gene Transcription.” Cell 144, no. 6 (March 2011): 886–896. © 2011 Elsevier Inc.
Version
Final published version
Abstract
Regulatory circuits controlling gene expression constantly rewire to adapt to environmental stimuli, differentiation cues, and disease. We review our current understanding of the temporal dynamics of gene expression in eukaryotes and prokaryotes and the molecular mechanisms that shape them. We delineate several prototypical temporal patterns, including “impulse” (or single-pulse) patterns in response to transient environmental stimuli, sustained (or state-transitioning) patterns in response to developmental cues, and oscillating patterns. We focus on impulse responses and their higher-order temporal organization in regulons and cascades and describe how core protein circuits and cis-regulatory sequences in promoters integrate with chromatin architecture to generate these responses.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2011.02.015
