Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo
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Hammond_Combination growth.pdf
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1.63 MB
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Adobe PDF
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68559d11e37b638d96bc461b618f0701
Author(s)
Almquist, Benjamin D
Castleberry, Steven A
Sun, Julia B.
Lu, Alice Y.
Hammond, Paula T
Date Issued
August 2015
Journal
Advanced Healthcare Materials
Publisher
Wiley Blackwell
Citation
Almquist, Benjamin D. et al. “Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo.” Advanced Healthcare Materials 4.14 (2015): 2090–2099.
Version
Author's final manuscript
Abstract
Chronic skin ulcerations are a common complication of diabetes mellitus, affecting up to one in four diabetic individuals. Despite the prevalence of these wounds, current pharmacologic options for treating them remain limited. Growth factor–based therapies have displayed a mixed ability to drive successful healing, which may be due to nonoptimal delivery strategies. Here, a method for coating commercially available nylon dressings using the layer-by-layer process is described to enable both sustained release and independent control over the release kinetics of vascular endothelial growth factor 165 and platelet-derived growth factor BB. It is shown that the use of strategically spaced diffusion barriers formed spontaneously by disulfide bonds enables independent control over the release rates of incorporated growth factors, and that in vivo these dressings improve several aspects of wound healing in db/db mice.
MIT Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adhm.201500403
