Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation
Name
elife-60824-v1.pdf
Description
Published version
Size
7.66 MB
Format
Adobe PDF
Checksum (MD5)
69ff12be36fa339ef193d13044a47642
Author(s)
Bastos, André M
Donoghue, Jacob A
Brincat, Scott L
Mahnke, Meredith
Yanar, Jorge
Correa, Josefina
Waite, Ayan S
Lundqvist, Mikael
Roy, Jefferson
Brown, Emery Neal
Date Issued
2021
Journal
eLife
Publisher
eLife Sciences Publications, Ltd
Citation
Bastos, André M, Donoghue, Jacob A, Brincat, Scott L, Mahnke, Meredith, Yanar, Jorge et al. 2021. "Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation." eLife, 10.
Version
Final published version
Abstract
The specific circuit mechanisms through which anesthetics induce unconsciousness have not been completely characterized. We recorded neural activity from the frontal, parietal, and temporal cortices and thalamus while maintaining unconsciousness in non-human primates (NHPs) with the anesthetic propofol. Unconsciousness was marked by slow frequency (~1 Hz) oscillations in local field potentials, entrainment of local spiking to Up states alternating with Down states of little or no spiking activity, and decreased coherence in frequencies above 4 Hz. Thalamic stimulation ‘awakened’ anesthetized NHPs and reversed the electrophysiologic features of unconsciousness. Unconsciousness is linked to cortical and thalamic slow frequency synchrony coupled with decreased spiking, and loss of higher-frequency dynamics. This may disrupt cortical communication/integration.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.7554/ELIFE.60824
