Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis
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TSWJ.2010.573915.pdf
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Author(s)
Halassa, Michael M.
Dal Maschio, Marco
Beltramo, Riccardo
Haydon, Philip G.
Benfenati, Fabio
Fellin, Tommaso
Date Issued
August 2010
Journal
The Scientific World JOURNAL
Publisher
Hindawi Publishing Corporation
Citation
Halassa, Michael M., Marco Dal Maschio, Riccardo Beltramo, Philip G. Haydon, Fabio Benfenati, and Tommaso Fellin. “Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis.” The Scientific World JOURNAL 10 (2010): 1634–1645.
Version
Final published version
Abstract
Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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DOI of Published Version
https://doi.org/10.1100/tsw.2010.130
