Endoscopically Injectable Shear‐Thinning Hydrogels Facilitating Polyp Removal
Name
advs.201901041.pdf
Description
Published version
Size
5.3 MB
Format
Adobe PDF
Checksum (MD5)
b4464c8c6a1ad4e0a9597194790daddb
Author(s)
Pang, Yan
Liu, Jinyao
Moussa, Zaina L
Collins, Joy E
McDonnell, Shane
Hayward, Alison M
Jajoo, Kunal
Langer, Robert
Traverso, Giovanni
Date Issued
2019
Journal
Advanced Science
Publisher
Wiley
Version
Final published version
Abstract
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Submucosal elevation, the process of instilling material in the submucosal space for separation of the surface mucosa and deeper muscularis layer, is a significant aspect of the endoscopic mucosal resection of large lesions performed to facilitate lesion removal and maximize safety. Submucosal injection, when applied, has historically been performed with normal saline, though this is limited by its rapid dissipation; solutions ideally need to be easily injectable, biocompatible, and provide a long-lasting submucosal cushion with a desirable height. Here, reported is a new set of materials, endoscopically injectable shear-thinning hydrogels, meeting these requirements because of their biocompatible components and ability to form a solid hydrogel upon injection. These findings are supported by evaluation in a large animal model and ultimately demonstrate the potential of these shear-thinning hydrogels to serve as efficient submucosal injection fluids for cushion development. Given these unique characteristics, their broad application in mucosal resection techniques is anticipated.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Division of Comparative Medicine
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/ADVS.201901041
