Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering
Name
1-s2.0-S2405805X17300972-main.pdf
Description
Published version
Size
1.75 MB
Format
Unknown
Checksum (MD5)
37ce91ed4f7220889e80093ee71ecde9
Author(s)
Abdel-Mawgoud, Ahmad Mohammad
Stephanopoulos, Gregory
Date Issued
March 2018
Journal
Synthetic and Systems Biotechnology
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2017 The Authors Glycosylated lipids (GLs) are added-value lipid derivatives of great potential. Besides their interesting surface activities that qualify many of them to act as excellent ecological detergents, they have diverse biological activities with promising biomedical and cosmeceutical applications. Glycolipids, especially those of microbial origin, have interesting antimicrobial, anticancer, antiparasitic as well as immunomodulatory activities. Nonetheless, GLs are hardly accessing the market because of their high cost of production. We believe that experience of metabolic engineering (ME) of microbial lipids for biofuel production can now be harnessed towards a successful synthesis of microbial GLs for biomedical and other applications. This review presents chemical groups of bacterial and fungal GLs, their biological activities, their general biosynthetic pathways and an insight on ME strategies for their production.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.synbio.2017.12.001
