Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Name
Kwon and Vander Heiden Final Manuscript.pdf
Size
672.23 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Vander Heiden, Matthew G.
Lunt, Sophia Yunkyungkwon
Date Issued
November 2011
Journal
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Citation
Lunt, Sophia Y., and Matthew G. Vander Heiden. “Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation.” Annual Review of Cell and Developmental Biology 27.1 (2011): 441–464.
Version
Author's final manuscript
Abstract
Warburg's observation that cancer cells exhibit a high rate of glycolysis even in the presence of oxygen (aerobic glycolysis) sparked debate over the role of glycolysis in normal and cancer cells. Although it has been established that defects in mitochondrial respiration are not the cause of cancer or aerobic glycolysis, the advantages of enhanced glycolysis in cancer remain controversial. Many cells ranging from microbes to lymphocytes use aerobic glycolysis during rapid proliferation, which suggests it may play a fundamental role in supporting cell growth. Here, we review how glycolysis contributes to the metabolic processes of dividing cells. We provide a detailed accounting of the biosynthetic requirements to construct a new cell and illustrate the importance of glycolysis in providing carbons to generate biomass. We argue that the major function of aerobic glycolysis is to maintain high levels of glycolytic intermediates to support anabolic reactions in cells, thus providing an explanation for why increased glucose metabolism is selected for in proliferating cells throughout nature.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1146/annurev-cellbio-092910-154237
