Statistical methods for constructing disease comorbidity networks from longitudinal inpatient data
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41109_2018_Article_101.pdf
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1.54 MB
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Author(s)
Fotouhi, Babak
Riolo, Maria A.
Buckeridge, David L.
Momeni Taramsari, Naghmeh
Date Issued
November 2018
Journal
Applied Network Science
Publisher
Springer International Publishing
Citation
Fotouhi, Babak et al. "Statistical methods for constructing disease comorbidity networks from longitudinal inpatient data." Applied Network Science 2018, 3 (November 2018): 46 © 2018 The Author(s)
Version
Final published version
Abstract
Tools from network science can be utilized to study relations between diseases. Different studies focus on different types of inter-disease linkages. One of them is the comorbidity patterns derived from large-scale longitudinal data of hospital discharge records. Researchers seek to describe comorbidity relations as a network to characterize pathways of disease progressions and to predict future risks. The first step in such studies is the construction of the network itself, which subsequent analyses rest upon. There are different ways to build such a network. In this paper, we provide an overview of several existing statistical approaches in network science applicable to weighted directed networks. We discuss the differences between the null models that these models assume and their applications. We apply these methods to the inpatient data of approximately one million people, spanning approximately 17 years, pertaining to the Montreal Census Metropolitan Area. We discuss the differences in the structure of the networks built by different methods, and different features of the comorbidity relations that they extract. We also present several example applications of these methods. Keywords: Weighted networks; Null model; Comorbidity; Disease networks; Centrality
MIT Department
Sloan School of Management
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1007/s41109-018-0101-4
