The TASCC of Secretion
Name
Sabatini_the TASCC.pdf
Size
206.76 KB
Format
Adobe PDF
Checksum (MD5)
e718f42eba135cccfa3d0e3f02e9a4e7
Author(s)
Zoncu, Roberto
Sabatini, David
Date Issued
May 2011
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Zoncu, R., and D. M. Sabatini. “The TASCC of Secretion.” Science 332, no. 6032 (May 19, 2011): 923-925.
Version
Author's final manuscript
Abstract
The oncogene-induced activation of signaling pathways involving the tumor suppressor proteins p53 and retinoblastoma is likely an important mechanism for preventing the proliferation of potential cancer cells (1, 2). This activation causes cells to exit the cell division cycle and enter a senescent state, which is characterized by major changes in chromatin structure that are thought to render senescence irreversible. Despite the absence of proliferation, senescent cells are not as quiescent as first thought, as they signal to their surrounding environment by activating a protein secretion program (3, 4). On page 966 of this issue, Narita et al. (5) show that to enable this secretory state, a senescent cell profoundly reorganizes its endomembrane system.
Description
Author Manuscript 2012 July 05
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/science.1207552
