Creating a False Memory in the Hippocampus
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Science revised (final)[1].pdf
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Author(s)
Ramirez Moreno, Steve
Liu, Xu
Lin, Pei-Ann
Suh, Junghyup
Ryan, Tomas John
Redondo, Roger L.
Tonegawa, Susumu
Pignatelli di Spinazzola, Michele
Date Issued
July 2013
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Ramirez, S., X. Liu, P.-A. Lin, J. Suh, M. Pignatelli, R. L. Redondo, T. J. Ryan, and S. Tonegawa. “Creating a False Memory in the Hippocampus.” Science 341, no. 6144 (July 26, 2013): 387–391. doi:10.1126/science.1239073.
Version
Author's final manuscript
Abstract
Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram–bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.1239073
