Chelators for investigating zinc metalloneurochemistry
Name
Lippard_Chelators for.pdf
Size
956.11 KB
Format
Adobe PDF
Checksum (MD5)
695a5c8cf53c970def6ad699d5632e7e
Author(s)
Radford, Robert John
Lippard, Stephen J.
Date Issued
March 2013
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier
Citation
Radford, Robert J and Lippard, Stephen J. “Chelators for Investigating Zinc Metalloneurochemistry.” Current Opinion in Chemical Biology 17, 2 (April 2013): 129–136 © 2013 Elsevier Ltd
Version
Author's final manuscript
Abstract
The physiology and pathology of mobile zinc signaling has become an important topic in metalloneurochemistry. To study the action of mobile zinc effectively, specialized tools are required that probe the temporal and positional changes of zinc ions within live tissue and cells. In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
Highlights
► Background on zinc metalloneurochemistry with an emphasis on hippocampal zinc. ► Design rules for zinc chelators that can be used as antagonists for mobile zinc. ► Utility of Zn-selective chelators for understanding zinc metalloneurochemisty.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cbpa.2013.01.009
