Probing the brain with molecular fMRI
Name
nihms955058.pdf
Description
Accepted version
Size
1.39 MB
Format
Adobe PDF
Checksum (MD5)
7d91cd61ca96591a448e726294f5b47b
Author(s)
Ghosh, Souparno
Harvey, Peter
Simon, Jacob Cyert
Jasanoff, Alan
Date Issued
June 2018
Journal
Current Opinion in Neurobiology
Publisher
Elsevier BV
Citation
Ghosh, Souparno, et al. “Probing the Brain with Molecular FMRI.” Current Opinion in Neurobiology 50 (June 2018): 201–10.
Version
Author's final manuscript
Abstract
One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecular-level functional magnetic resonance imaging (molecular fMRI) is a new technology that can help bridge these scales by mapping defined microscopic phenomena over large, optically inaccessible regions of the living brain. In this review, we explain how MRI-detectable imaging probes can be used to sensitize noninvasive imaging to mechanistically significant components of neural processing. We discuss how a combination of innovative probe design, advanced imaging methods, and strategies for brain delivery can make molecular fMRI an increasingly successful approach for spatiotemporally resolved studies of diverse neural phenomena, perhaps eventually in people.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CONB.2018.03.009
