Nanotechnological strategies for engineering complex tissues
Name
nihms571867.pdf
Description
Accepted version
Size
1.12 MB
Format
Adobe PDF
Checksum (MD5)
6172bdeca4c6141a5ca411d9116e60f1
Author(s)
Dvir, Tal
Timko, Brian T.
Kohane, Daniel S.
Langer, Robert S
Date Issued
January 2011
Journal
Nature Nanotechnology
Publisher
Springer Nature America, Inc
Citation
Dvir, Tal, et al. “Nanotechnological Strategies for Engineering Complex Tissues.” Nature Nanotechnology 6, 1 (January 2011): 13–22.
Version
Author's final manuscript
Abstract
Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/nnano.2010.246
