Input-specific control of reward and aversion in the ventral tegmental area
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Author(s)
Tye, Kay
Lammel, Stephan
Lim, Byung Kook
Ran, Chen
Huang, Kee Wui
Betley, Michael J.
Malenka, Robert C.
Deisseroth, Karl
Date Issued
October 2012
Journal
Nature
Publisher
Nature Publishing Group
Citation
Lammel, Stephan, Byung Kook Lim, Chen Ran, Kee Wui Huang, Michael J. Betley, Kay M. Tye, Karl Deisseroth, and Robert C. Malenka. “Input-Specific Control of Reward and Aversion in the Ventral Tegmental Area.” Nature 491, no. 7423 (October 14, 2012): 212–217.
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Author's final manuscript
Abstract
Ventral tegmental area (VTA) dopamine neurons have important roles in adaptive and pathological brain functions related to reward and motivation. However, it is unknown whether subpopulations of VTA dopamine neurons participate in distinct circuits that encode different motivational signatures, and whether inputs to the VTA differentially modulate such circuits. Here we show that, because of differences in synaptic connectivity, activation of inputs to the VTA from the laterodorsal tegmentum and the lateral habenula elicit reward and aversion in mice, respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to the nucleus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons projecting to the medial prefrontal cortex as well as on GABAergic (γ-aminobutyric-acid-containing) neurons in the rostromedial tegmental nucleus. These results establish that distinct VTA circuits generate reward and aversion, and thereby provide a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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DOI of Published Version
https://doi.org/10.1038/nature11527
