Propofol and sevoflurane induce distinct burst suppression patterns in rats
Name
Kenny-2014-Propofol and sevoflu.pdf
Size
1.7 MB
Format
Adobe PDF
Checksum (MD5)
0197df18af8934270e6cf364f6a2b0ad
Author(s)
Westover, M. Brandon
Ching, ShiNung
Brown, Emery N.
Solt, Ken
Kenny, Jonathan Dillion
Date Issued
December 2014
Journal
Frontiers in Systems Neuroscience
Publisher
Frontiers Research Foundation
Citation
Kenny, Jonathan D., M. Brandon Westover, ShiNung Ching, Emery N. Brown, and Ken Solt. “Propofol and Sevoflurane Induce Distinct Burst Suppression Patterns in Rats.” Front. Syst. Neurosci. 8 (December 18, 2014).
Version
Final published version
Abstract
Burst suppression is an EEG pattern characterized by alternating periods of high-amplitude activity (bursts) and relatively low amplitude activity (suppressions). Burst suppression can arise from several different pathological conditions, as well as from general anesthesia. Here we review current algorithms that are used to quantify burst suppression, its various etiologies, and possible underlying mechanisms. We then review clinical applications of anesthetic-induced burst suppression. Finally, we report the results of our new study showing clear electrophysiological differences in burst suppression patterns induced by two common general anesthetics, sevoflurane and propofol. Our data suggest that the circuit mechanisms that generate burst suppression activity may differ among general anesthetics.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fnsys.2014.00237
