Ligand-clustered “patchy” nanoparticles for modulated cellular uptake and in vivo tumor targeting
Name
Bhatia_Ligand-clustered.pdf
Size
1.39 MB
Format
Adobe PDF
Checksum (MD5)
46b1730c7e75279eb06a1cb8b86a6d06
Author(s)
Poon, Zhiyong
Chen, Shujun
Engler, Amanda C.
Lee, Hyung-il
Atas, Evrim
von Maltzahn, Geoffrey
Bhatia, Sangeeta N.
Hammond, Paula T.
Date Issued
August 2010
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Poon, Zhiyong et al. “Ligand-Clustered ‘Patchy’ Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting.” Angewandte Chemie International Edition 49.40 (2010): 7266–7270. Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Version
Author's final manuscript
Abstract
A matter of presentation: The manner in which polyvalent ligands are presented to a cell—homogeneously or in spatially defined groupings on a nanoparticle surface—may play an important role in cellular uptake. This aspect is investigated for the first time using a linear dendritic polymer construct to pattern the surfaces of nanoparticles with variable-sized ligand clusters in different spatial arrangements.
Description
Author Manuscript: 2012 August 05.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/anie.201003445
