A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project
Name
bio.2015.0032.pdf
Description
Published version
Size
904.01 KB
Format
Adobe PDF
Checksum (MD5)
0b300d076a7984196599930a4389d42f
Author(s)
Ardlie, Kristin G.
DeLuca, David S.
Gelfand, Ellen T.
Segre, Ayellet V.
Young, Taylor R.
GTex Consortium
Date Issued
January 1, 2015
Journal
Biopreservation and Biobanking
Publisher
Mary Ann Liebert Inc
Citation
Carithers, L. J., et al. "A Novel Approach to High-Quality Postmortem Tissue Procurement: The Gtex Project." Biopreserv Biobank 13 5 (2015): 311-9.
Version
Final published version
Abstract
© Copyright 2015, Mary Ann Liebert, Inc. 2015. The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.
MIT Department
Broad Institute of MIT and Harvard
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1089/bio.2015.0032
