Steering trajectories of rolling cells by 2D asymmetric receptor patterning
Name
Chia-Hua-2010-Steering Trajectories of Rolling Cells by 2D Asymmetric Receptor Patterning.pdf
Size
529.41 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Lee, Chia-Hua
Bose, Suman
Karp, Jeffrey Michael
Karnik, Rohit
Date Issued
March 2010
Journal
2010 IEEE 36th Annual Northeast Bioengineering Conference
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Citation
Lee, Chia-Hua et al. “Steering Trajectories of Rolling Cells by 2D Asymmetric Receptor Patterning.” IEEE, 2010. 1–2. Web. 4 Apr. 2012. © 2010 Institute of Electrical and Electronics Engineers
Version
Final published version
Abstract
We demonstrate a simple method to make high-resolution P-selectin patterns based on microcontact printing for controlling cell rolling. SEM characterization revealed well-defined patterns that could direct the trajectories of rolling HL60 cells along the edges. Cell tracking revealed that velocities of rolling cells were higher at the edges as compared to plain P-selectin regions, with a maximum at an edge angle of 20°. The distance traveled by the HL60 cells along the edges decreased with increasing edge angles. These substrates may be used to tune cell adhesion and control the transport of the cells for separation and analysis.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1109/NEBC.2010.5458199
