SnapShot: DNA Polymerases II Mammals
Name
Walker_Snapshot DNA.pdf
Size
147.26 KB
Format
Adobe PDF
Checksum (MD5)
1a5972601bd0410ab9b62b75a528db5d
Author(s)
Foti, James J.
Walker, Graham C.
Date Issued
April 2010
Journal
Cell
Publisher
Elsevier B.V.
Citation
Foti, James J., and Graham C. Walker. “SnapShot: DNA Polymerases II Mammals.” Cell 141, no. 2 (April 2010): 370–370.e1.
Version
Final published version
Abstract
DNA polymerases ensure the faithful duplication of genetic information inside the nuclease and mitochondria of eukaryotic cells and the nucleoid of prokaryotic cells. These remarkable enzymes synthesize polynucleotide chains based on the complementarity of an incoming nucleotide to an existing DNA template. DNA polymerases are grouped into six families (A, B, C, D, X, and Y). The previous SnapShot (DNA Polymerases I Prokaryotes) described the structural and functional characteristics conserved across the families, using the DNA polymerases from the bacterium Escherichia coli as an example. In this SnapShot, we now highlight DNA polymerases from humans (Homo sapiens) and their relationship to human diseases. However, this list is certainly not exhaustive, and the number of putative links between DNA polymerases and diseases continues to grow.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2010.04.005
