Inflammation-induced DNA damage, mutations and cancer
Name
nihms-1536684.pdf
Description
Accepted version
Size
2.12 MB
Format
Adobe PDF
Checksum (MD5)
e09e81cefe71883be109b979769e7c58
Author(s)
Kay, Jennifer Elizabeth
Thadhani, Elina
Samson, Leona D
Engelward, Bevin P
Date Issued
July 2019
Journal
DNA Repair
Publisher
Elsevier BV
Citation
Kay, Jennifer Elizabeth et al. "Inflammation-induced DNA damage, mutations and cancer." DNA Repair 83 (November 2019): 102673 © 2019 Elsevier B.V.
Version
Author's final manuscript
Abstract
The relationships between inflammation and cancer are varied and complex. An important connection linking inflammation to cancer development is DNA damage. During inflammation reactive oxygen and nitrogen species (RONS) are created to combat pathogens and to stimulate tissue repair and regeneration, but these chemicals can also damage DNA, which in turn can promote mutations that initiate and promote cancer. DNA repair pathways are essential for preventing DNA damage from causing mutations and cytotoxicity, but RONS can interfere with repair mechanisms, reducing their efficacy. Further, cellular responses to DNA damage, such as damage signaling and cytotoxicity, can promote inflammation, creating a positive feedback loop. Despite coordination of DNA repair and oxidative stress responses, there are nevertheless examples whereby inflammation has been shown to promote mutagenesis, tissue damage, and ultimately carcinogenesis. Here, we discuss the DNA damage-mediated associations between inflammation, mutagenesis and cancer.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.DNAREP.2019.102673
