The role of engram cells in the systems consolidation of memory
Name
Tonegawa NRN 2018 - Main Text Final.pdf
Description
Accepted version
Size
401.11 KB
Format
Adobe PDF
Checksum (MD5)
74ff1d84e6820a14f110fe024f502095
Author(s)
Tonegawa, Susumu
Morrissey, Mark
Kitamura, Takashi
Date Issued
July 2018
Journal
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Citation
Tonegawa, Susumu et al. "The role of engram cells in the systems consolidation of memory." Nature Reviews Neuroscience 19, 8 (July 2018): 485–498 © 2018 Macmillan Publishers Ltd., part of Springer Nature
Version
Author's final manuscript
Abstract
What happens to memories as days, weeks and years go by has long been a fundamental question in neuroscience and psychology. For decades, researchers have attempted to identify the brain regions in which memory is formed and to follow its changes across time. The theory of systems consolidation of memory (SCM) suggests that changes in circuitry and brain networks are required for the maintenance of a memory with time. Various mechanisms by which such changes may take place have been hypothesized. Recently, several studies have provided insight into the brain networks driving SCM through the characterization of memory engram cells, their biochemical and physiological changes and the circuits in which they operate. In this Review, we place these findings in the context of the field and describe how they have led to a revamped understanding of SCM in the brain.
MIT Department
RIKEN-MIT Center for Neural Circuit Genetics
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
http://dx.doi.org/10.1038/s41583-018-0031-2
