Towards accurate imputation of quantitative genetic interactions
Name
Ulitsky-2009-Towards accurate imputation of quantitative genetic interactions.pdf
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1.53 MB
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Adobe PDF
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1c2802a841636bbe5ac4793e6db173b3
Author(s)
Krogan, Nevan J.
Shamir, Ron
Ulitsky, Igor
Date Issued
December 2009
Journal
Genome Biology
Publisher
Springer (Biomed Central Ltd.)
Citation
Ulitsky, Igor, Nevan J Krogan, and Ron Shamir. “Towards Accurate Imputation of Quantitative Genetic Interactions.” Genome Biology 10.12 (2009): R140. Web. 1 Mar. 2012.
Version
Final published version
Abstract
Recent technological breakthroughs have enabled high-throughput quantitative measurements of hundreds of thousands of genetic interactions among hundreds of genes in Saccharomyces cerevisiae. However, these assays often fail to measure the genetic interactions among up to 40% of the studied gene pairs. Here we present a novel method, which combines genetic interaction data together with diverse genomic data, to quantitatively impute these missing interactions. We also present data on almost 190,000 novel interactions.
MIT Department
Whitehead Institute for Biomedical Research
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/gb-2009-10-12-r140
