Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19
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1076029620943671.pdf
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Author(s)
Frydman, Galit H.
Boyer, Edward W.
Nazarian, Rosalynn M.
Van Cott, Elizabeth M.
Piazza, Gregory
Date Issued
July 2020
Journal
Clinical and Applied Thrombosis/Hemostasis
Publisher
SAGE Publications
Citation
Frydman, Galit H. et al. "Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19." Clinical and Applied Thrombosis/Hemostasis 26 (July 2020): 1-8 © 2020 The Author(s)
Version
Author's final manuscript
Abstract
Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidity and mortality in patients with COVID-19, it is unclear whether preexisting differences in coagulation impact the severity of COVID-19. African Americans have higher rates of COVID-19 infection and disease-related morbidity and mortality. Moreover, African Americans are known to be at a higher risk for thrombotic events due to both biological and socioeconomic factors. In this review, we explore whether differences in baseline coagulation status and medical management of coagulation play an important role in COVID-19 disease severity and contribute to racial disparity trends within COVID-19.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
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DOI of Published Version
https://doi.org/10.1177/1076029620943671
