A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
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Liao-2014-Convergent synthetic.pdf
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Author(s)
Liao, Longyan
Liu, Jenny
Morton, Stephen Winford
Hammond, Paula T.
Johnson, Jeremiah A.
Dreaden, Erik Christopher
Shopsowitz, Kevin
Date Issued
April 2014
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Liao, Longyan, Jenny Liu, Erik C. Dreaden, Stephen W. Morton, Kevin E. Shopsowitz, Paula T. Hammond, and Jeremiah A. Johnson. “A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin.” Journal of the American Chemical Society 136, no. 16 (April 23, 2014): 5896–5899. © 2014 American Chemical Society
Version
Final published version
Abstract
The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer.
MIT Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja502011g
