Subcortical connections of area V4 in the macaque
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Desimone_Subcortical connections.pdf
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Author(s)
Gattass, Ricardo
Galkin, Thelma W.
Desimone, Robert
Ungerleider, Leslie G.
Date Issued
April 2014
Journal
Journal of Comparative Neurology
Publisher
Wiley Blackwell
Citation
Gattass, Ricardo, Thelma W. Galkin, Robert Desimone, and Leslie G. Ungerleider. “Subcortical Connections of Area V4 in the Macaque.” J. Comp. Neurol. 522, no. 8 (April 3, 2014): 1941–1965. © 2013 Wiley Periodicals, Inc.
Version
Final published version
Abstract
Area V4 has numerous, topographically organized connections with multiple cortical areas, some of which are important for spatially organized visual processing, and others which seem important for spatial attention. Although the topographic organization of V4's connections with other cortical areas has been established, the detailed topography of its connections with subcortical areas is unclear. We therefore injected retrograde and anterograde tracers in different topographical regions of V4 in nine macaques to determine the organization of its subcortical connections. The injection sites included representations ranging from the fovea to far peripheral eccentricities in both the upper and lower visual fields. The topographically organized connections of V4 included bidirectional connections with four subdivisions of the pulvinar, two subdivisions of the claustrum, and the interlaminar portions of the lateral geniculate nucleus, and efferent projections to the superficial and intermediate layers of the superior colliculus, the thalamic reticular nucleus, and the caudate nucleus. All of these structures have a possible role in spatial attention. The nontopographic, or converging, connections included bidirectional connections with the lateral nucleus of the amygdala, afferent inputs from the dorsal raphe, median raphe, locus coeruleus, ventral tegmentum and nucleus basalis of Meynert, and efferent projections to the putamen. Any role of these structures in attention may be less spatially specific.
MIT Department
McGovern Institute for Brain Research at MIT
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DOI of Published Version
https://doi.org/10.1002/cne.23513
