A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings
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Author(s)
Yesilyurt, Volkan
Veiseh, Omid
Doloff, Joshua C
Li, Jie
Bose, Suman
Xie, Xi
Bader, Andrew R.
Chen, Michael Y
Webber, Matthew
Vegas, Arturo
Date Issued
December 2016
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Yesilyurt, Volkan et al. "A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings." Advanced Healthcare Materials 6, 4 (December 2016): 1601091 © Wiley
Version
Author's final manuscript
Abstract
The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice. Keywords: alginate; dopamine; fibrosis; foreign body response; zwitterionic polymers
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Biological Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adhm.201601091
