Amniotic Fluid-Derived Stem Cells for Cardiovascular Tissue Engineering Applications
Name
Connell-2013-Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications.pdf
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512 KB
Format
Adobe PDF
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Author(s)
Petsche Connell, Jennifer
Camci-Unal, Gulden
Khademhosseini, Ali
Jacot, Jeffrey G.
Date Issued
March 2013
Journal
Tissue Engineering Part B: Reviews
Publisher
Mary Ann Liebert, Inc.
Citation
Petsche Connell, Jennifer, Gulden Camci-Unal, Ali Khademhosseini, and Jeffrey G. Jacot. “Amniotic Fluid-Derived Stem Cells for Cardiovascular Tissue Engineering Applications.” Tissue Engineering Part B: Reviews 19, no. 4 (August 2013): 368-379.
Version
Final published version
Abstract
Recent research has demonstrated that a population of stem cells can be isolated from amniotic fluid removed by amniocentesis that are broadly multipotent and nontumorogenic. These amniotic fluid-derived stem cells (AFSC) could potentially provide an autologous cell source for treatment of congenital defects identified during gestation, particularly cardiovascular defects. In this review, the various methods of isolating, sorting, and culturing AFSC are compared, along with techniques for inducing differentiation into cardiac myocytes and endothelial cells. Although research has not demonstrated complete and high-yield cardiac differentiation, AFSC have been shown to effectively differentiate into endothelial cells and can effectively support cardiac tissue. Additionally, several tissue engineering and regenerative therapeutic approaches for the use of these cells in heart patches, injection after myocardial infarction, heart valves, vascularized scaffolds, and blood vessels are summarized. These applications show great promise in the treatment of congenital cardiovascular defects, and further studies of isolation, culture, and differentiation of AFSC will help to develop their use for tissue engineering, regenerative medicine, and cardiovascular therapies.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1089/ten.teb.2012.0561
