Imaging mobile zinc in biology
Name
Tomat and Lippard COCB.pdf
Size
144.76 KB
Format
Adobe PDF
Checksum (MD5)
029a5b425efbb5a27d8e6db0903def6d
Author(s)
Tomat, Elisa
Lippard, Stephen J.
Date Issued
January 2010
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier Ltd.
Citation
Tomat, Elisa, and Stephen J Lippard. “Imaging Mobile Zinc in Biology.” Current Opinion in Chemical Biology 14.2 (2010) : 225-230.
Version
Author's final manuscript
Abstract
Trafficking and regulation of mobile zinc pools influence cellular functions and pathological conditions in multiple organs, including brain, pancreas, and prostate. The quest for a dynamic description of zinc distribution and mobilization in live cells fuels the development of increasingly sophisticated probes. Detection systems that respond to zinc binding with changes of their fluorescence emission properties have provided sensitive tools for mobile zinc imaging, and fluorescence microscopy experiments have afforded depictions of zinc distribution within live cells and tissues. Both small-molecule and protein-based fluorescent probes can address complex imaging challenges, such as analyte quantification, site-specific sensor localization, and real-time detection.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cbpa.2009.12.010
