A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety
Name
sciadv.adj3003.pdf
Description
Published version
Size
1.37 MB
Format
Adobe PDF
Checksum (MD5)
2569e3411a02a671442ebfcf9c580e3d
Author(s)
Srinivasan, Shriya S.
Alshareef, Amro
Hwang, Alexandria
Byrne, Ceara
Kuosmanen, Johannes
Ishida, Keiko
Jenkins, Joshua
Liu, Sabrina
Madani, Wiam Abdalla Mohammed
Hayward, Alison M.
Date Issued
December 22, 2023
Journal
Science Advances
Publisher
American Association for the Advancement of Science
Citation
Shriya S. Srinivasan et al. ,A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety.Sci. Adv.9,eadj3003(2023).
Version
Final published version
Abstract
Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with obesity to effectively manage their disease. Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension. We designed the Vibrating Ingestible BioElectronic Stimulator (VIBES) pill, an ingestible device that performs luminal vibratory stimulation to activate mechanoreceptors and stroke mucosal receptors, which induces serotonin release and yields a hormonal metabolic response commensurate with a fed state. We evaluated VIBES across 108 meals in swine which consistently led to diminished food intake (~40%,
P < 0.0001) and minimized the weight gain rate ( P < 0.05) as compared to untreated controls. Application of mechanoreceptor biology could transform our capacity to help patients suffering from nutritional disorders.
P < 0.0001) and minimized the weight gain rate ( P < 0.05) as compared to untreated controls. Application of mechanoreceptor biology could transform our capacity to help patients suffering from nutritional disorders.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Division of Comparative Medicine
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DOI of Published Version
https://doi.org/10.1126/sciadv.adj3003
