A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape
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Author(s)
Ow, Hooisweng
Morton, Stephen Winford
Gu, Li
Hammond, Paula T
Deng, Zhou J.
Bonner, Daniel K.
Date Issued
February 2015
Journal
Biomaterials
Publisher
Elsevier
Citation
Deng, Zhou J.; Morton, Stephen W.; Bonner, Daniel K.; Gu, Li; Ow, Hooisweng and Hammond, Paula T. “A Plug-and-Play Ratiometric pH-Sensing Nanoprobe for High-Throughput Investigation of Endosomal Escape.” Biomaterials 51 (May 2015): 250–256. © 2015 Elsevier Ltd
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Author's final manuscript
Abstract
An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means to screen materials towards efficient delivery of therapeutics such as nucleic acids.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.biomaterials.2015.02.013
