Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma
Name
nihms-1582959.pdf
Description
Accepted version
Size
2.67 MB
Format
Adobe PDF
Checksum (MD5)
c5da9eb68a47c73839e1bfd42204e138
Author(s)
Chung, Katherine Minjee
Singh, Jaffarguriqbal
Lawres, Lauren
Dorans, Kimberly Judith
Garcia, Cathy
Burkhardt, Daniel B
Robbins, Rebecca
Bhutkar, Arjun
Cardone, Rebecca
Zhao, Xiaojian
Date Issued
2020
Journal
Cell
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2020 Elsevier Inc. Obesity is an intrinsic driver of PDAC in mice, leading to a remodeling of beta cells to increase CCK secretion and playing a role early in pancreatic cancer development that can be intercepted by weight loss.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Howard Hughes Medical Institute
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELL.2020.03.062
