Distinct Early Serological Signatures Track with SARS-CoV-2 Survival
Name
1-s2.0-S1074761320303277-main.pdf
Description
Published version
Size
2.62 MB
Format
Adobe PDF
Checksum (MD5)
647c4a0efb97f94959cb5237c6ae6d7e
Author(s)
Atyeo, Caroline
Fischinger, Stephanie
Zohar, Tomer
Slein, Matthew D.
Burke, John
Loos, Carolin
McCulloch, Denise J.
Newman, Kira L.
Wolf, Caitlin
Yu, Jingyou
Date Issued
September 2020
Journal
Immunity
Publisher
Elsevier BV
Citation
Atyeo, Caroline et al. "Distinct Early Serological Signatures Track with SARS-CoV-2 Survival." Immunity 53, 3 (September 2020): P524-532.e4 © 2020 The Authors
Version
Final published version
Abstract
As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to immunological mechanisms of protection. Here, we profiled SARS-CoV-2-specific humoral responses in a cohort of 22 hospitalized individuals. Despite inter-individual heterogeneity, distinct antibody signatures resolved individuals with different outcomes. Although no differences in SARS-CoV-2-specific IgG levels were observed, spike-specific humoral responses were enriched among convalescent individuals, whereas functional antibody responses to the nucleocapsid were elevated in deceased individuals. Furthermore, this enriched immunodominant spike-specific antibody profile in convalescents was confirmed in a larger validation cohort. These results demonstrate that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies point to differences in disease trajectory, highlighting the potential importance of functional antigen-specific humoral immunity to guide patient care and vaccine development.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.immuni.2020.07.020
