Mouse ooplasm confers context-specific reprogramming capacity
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Author(s)
Chan, Michelle M
Smith, Zachary D
Egli, Dieter
Regev, Aviv
Meissner, Alexander
Chan, Michelle Mei Wah
Date Issued
August 2012
Journal
Nature Genetics
Publisher
Nature Publishing Group
Citation
Chan, Michelle M et al. “Mouse Ooplasm Confers Context-Specific Reprogramming Capacity.” Nature Genetics 44, 9 (August 2012): 978–980 © 2012 Nature America, Inc
Version
Author's final manuscript
Abstract
Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.
MIT Department
Massachusetts Institute of Technology. Computational and Systems Biology Program
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/ng.2382
