Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature
Name
Kohandel-2011-Quantitative Model for Efficient Temporal .pdf
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3.01 MB
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Author(s)
Kohandel, Mohammad
Haselwandter, Christoph A.
Kardar, Mehran
Sengupta, S.
Sivaloganathan, S.
Date Issued
January 2011
Journal
Computational and Mathematical Methods in Medicine
Publisher
Hindawi Pub. Corp.
Citation
Kohandel, M. et al. “Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature.” Computational and Mathematical Methods in Medicine 2011 (2011) : 1-10.
Version
Final published version
Abstract
The combination of cytotoxic therapies and antiangiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome. Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system. Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue. The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.
MIT Department
Massachusetts Institute of Technology. Department of Physics
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1155/2011/790721
