A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
Name
Myers-2011-A User's Guide to th.pdf
Size
2.3 MB
Format
Adobe PDF
Checksum (MD5)
2af412a60fcb6374c90bc8ba6e1508f7
Author(s)
Bernstein, Bradley E.
Epstein, Charles B.
Shoresh, Noam
Ernst, Jason
Mikkelsen, Tarjei Sigurd
Kheradpour, Pouya
Zhang, Xiaolan
Wang, Li
Issner, Robbyn
Coyne, Michael J.
Date Issued
April 2011
Journal
PLoS Biology
Publisher
Public Library of Science
Citation
The ENCODE Project Consortium (2011) "A User’s Guide to the Encyclopedia of DNA Elements (ENCODE)." PLoS Biology 9(4): e1001046.
Version
Final published version
Abstract
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to
interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE
Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional
elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with
their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have
been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made
available through a freely accessible database. Here we provide an overview of the project and the resources it is generating
and illustrate the application of ENCODE data to interpret the human genome.
MIT Department
Broad Institute of MIT and Harvard
Lincoln Laboratory
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1371/journal.pbio.1001046
