Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes
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Buchwald_Enantioselective.pdf
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Author(s)
Zhu, Rong
Buchwald, Stephen Leffler
Date Issued
October 2013
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhu, Rong, and Stephen L. Buchwald. “Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper-Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes.” Angewandte Chemie International Edition 52, no. 48 (October 16, 2013): 12655–12658.
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Author's final manuscript
Abstract
Something radical: An efficient enantioselective oxytrifluoromethylation of alkenes has been developed using a copper catalyst system. Mechanistic studies are consistent with a metal-catalyzed redox radical addition mechanism in which a C[BOND]O bond is formed by the copper-mediated enantioselective trapping of a prochiral alkyl radical intermediate derived from the initial trifluoromethyl radical addition.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1002/anie.201307790
