Keeping the Proportions of Protein Complex Components in Check
Name
1-s2.0-S2405471220300314-main.pdf
Description
Published version
Size
879.91 KB
Format
Adobe PDF
Checksum (MD5)
281364a5e57c3a6d1d587b926358b070
Author(s)
Taggart, James Christopher
Zauber, Henrik
Selbach, Matthias
Li, Gene-Wei
McShane, Erik
Date Issued
2020
Journal
Cell Systems
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The Authors How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing the precise proportions in living cells: on the one hand, ribosome profiling studies indicate that proteins are already produced in the correct relative proportions. On the other hand, proteomic studies found that many complexes contain subunits that are made in excess and subsequently degraded. Here, we discuss these seemingly contradictory findings, emerging principles, and remaining open questions. We conclude that establishing precise protein levels involves both coordinated synthesis and post-translational fine-tuning via protein degradation.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELS.2020.01.004
