Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering
Name
Annabi-2010-Controlling the Poro.pdf
Size
495.47 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Annabi, Nasim
Nichol, Jason W.
Zong, Xia
Ji, Chengdong
Koshy, Sandeep Tharian
Khademhosseini, Ali
Dehghani, Fariba
Date Issued
March 2010
Journal
Tissue Engineering. Part B
Publisher
Mary Ann Liebert, Inc.
Citation
Annabi, Nasim et al. “Controlling the Porosity and Microarchitecture of Hydrogels for Tissue Engineering.” Tissue Engineering Part B: Reviews 16.4 (2011): 371-383. copyright 2011 Mary Ann Liebert, Inc.
Version
Final published version
Abstract
Tissue engineering holds great promise for regeneration and repair of diseased tissues, making the development of tissue engineering scaffolds a topic of great interest in biomedical research. Because of their biocompatibility and similarities to native extracellular matrix, hydrogels have emerged as leading candidates for engineered tissue scaffolds. However, precise control of hydrogel properties, such as porosity, remains a challenge. Traditional techniques for creating bulk porosity in polymers have demonstrated success in hydrogels for tissue engineering; however, often the conditions are incompatible with direct cell encapsulation. Emerging technologies have demonstrated the ability to control porosity and the microarchitectural features in hydrogels, creating engineered tissues with structure and function similar to native tissues. In this review, we explore the various technologies for controlling the porosity and microarchitecture within hydrogels, and demonstrate successful applications of combining these techniques.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1089/ten.teb.2009.0639
