Dendritic cell nediated inhibition of lentiviral infection
Name
Drake-2012-Dendritic cell nedia.pdf
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162.33 KB
Format
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Checksum (MD5)
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Author(s)
Drake, Adam
Browne, Edward P.
Phennicie, Ryan T.
Chen, Jianzhu
Date Issued
September 2012
Journal
Retrovirology
Publisher
Biomed Central Ltd.
Citation
Drake, A et al. “Dendritic Cell Nediated Inhibition of Lentiviral Infection.” Retrovirology 9.Suppl 2 (2012): P178.
Version
Final published version
Abstract
Lentiviral entry to quiescent lymphocytes represents a 'time bomb' waiting for cellular activation to spread infection. In order to undergo immune activation T cells interact with dendritic cells presenting peptide:MHC complexes 'sampling' them to look for agonist peptides and receiving survival signals from self peptides. This makes the dendritic cell:T cell interaction an ideal checkpoint to contain lentiviral infection of quiescent lypmhocytes.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/1742-4690-9-s2-p178
