Vitamin B 12 in the spotlight again
Name
Drennan_Vitamin B12.pdf
Description
Accepted version
Size
669.77 KB
Format
Adobe PDF
Checksum (MD5)
bb03693486b6adafb144ef75cdf920bd
Author(s)
Bridwell-Rabb, Jennifer
Drennan, Catherine L
Alternative Title
Vitamin B[subscript 12] in the spotlight again
Date Issued
February 2017
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier BV
Citation
Bridwell-Rabb, Jennifer and Catherine L. Drennan, "Vitamin B12 in the spotlight again." Current Opinion in Chemical Biology 37 (April 2017): p. 63-70 doi. 10.1016/j.cbpa.2017.01.013 ©2017 Authors
Version
Author's final manuscript
Abstract
The ability of cobalamin to coordinate different upper axial ligands gives rise to a diversity of reactivity. Traditionally, adenosylcobalamin is associated with radical-based rearrangements, and methylcobalamin with methyl cation transfers. Recently, however, a new role for adenosylcobalamin has been discovered as a light sensor, and a methylcobalamin-dependent enzyme has been identified that is suggested to transfer a methyl anion. Additionally, recent studies have provided a wealth of new information about a third class of cobalamin-dependent enzymes that do not appear to use an upper ligand. They function in reductive dehalogenations and epoxide reduction reactions. Finally, mechanistic details are beginning to emerge about the cobalamin-dependent S-adenosylmethionine radical enzyme superfamily for which the role of cobalamin has been largely enigmatic. ©2017 Elsevier Ltd
Description
April 2017 issue of Current Opinion in Chemical Biology is a special issue: "Biocatalysis & biotransformation * Bioinorganic Chemistry"
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.CBPA.2017.01.013
