Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells
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biosensors-08-00076.pdf
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Author(s)
Li, He
Chang, Hung-Yu
Lu, Lu
Deng, Yixiang
Papageorgiou, Dimitrios P.
Yang, Jun
Date Issued
August 2018
Journal
Biosensors
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Li, He et al. "Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells." Biosensors 8, 3 (August 2018): 76 © 2018 The Authors
Version
Final published version
Abstract
In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins or changes to the extracellular environment, lead to compromised cell deformability, impaired cell stability, and increased propensity to aggregate. Numerous laboratory approaches have been implemented to elucidate the pathogenesis of RBC disorders. Concurrently, computational RBC models have been developed to simulate the dynamics of RBCs under physiological and pathological conditions. In this work, we review recent laboratory and computational studies of disordered RBCs. Distinguished from previous reviews, we emphasize how experimental techniques and computational modeling can be synergically integrated to improve the understanding of the pathophysiology of hematological disorders. Keywords: red blood cell disorders; numerical modeling; laboratory approaches
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/bios8030076
