ComBo : a visualization tool for comparative genomic data
Name
62560278-MIT.pdf
Description
Full printable version
Size
10.52 MB
Format
Adobe PDF
Checksum (MD5)
169b26116ee711cb0648f9bb4a006422
Author(s)
Yu, Tamara H. (Tamara Hui)
Advisor(s)
James Galagan and Jill P. Mesirov.
Alternative Title
Com Bo : a visualization tool for comparative genomic data
Date Issued
2004
Publisher
Massachusetts Institute of Technology
Abstract
Propelled by advances in sequencing technology, the advent of the genomic era brings the challenge of managing and interpreting massive amount of genomic data. A number of single-genome browsers have been developed for data display. However, they are unsuitable for comparative analysis. We present a dynamic and interactive visualization tool called ComBo that allows users to quickly navigate sequences, browse their similarities in a dot plot format, display sequence annotations in feature maps, and compare annotations in corresponding regions. ComBo allows users to directly control the display. They can compare any two regions in the sequences at any resolution, from an entire chromosome down to the residue level. Users can also retrieve detailed information on any displayed sequence feature or alignment. ComBo can import data from the Calhoun annotation database or flat files. Developed in Java, ComBo has a flexible infrastructure allowing the easy addition of functionality in the future.
Description
Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.
Includes bibliographical references (p. 62-64).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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