mTOR and cancer: many loops in one pathway
Name
Sabatini_mTOR and.pdf
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474.27 KB
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Adobe PDF
Checksum (MD5)
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Author(s)
Efeyan, Alejo
Sabatini, David
Date Issued
April 2009
Journal
Current Opinion in Cell Biology
Publisher
Elsevier
Citation
Efeyan, Alejo, and David M Sabatini. “mTOR and Cancer: Many Loops in One Pathway.” Current Opinion in Cell Biology 22.2 (2010): 169–176.
Version
Author's final manuscript
Abstract
The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of pieces have been added to the puzzle of how mTOR coordinates and executes its functions. Extensive research on mTOR has also uncovered a complex network of regulatory loops that impact the therapeutic approaches aimed at targeting mTOR.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.ceb.2009.10.007
